I tried 70% rubbing alcohol in my permanent markers with good results, and, since the alcohol is what dissolves the left-over ink, I'm not sure that the 50% variety would do as well. Pliers can help pop off the end cap, and a saturated cotton ball is useful for applying the drops. The ink sponge isn't very large, so it takes only a few drops before absorption visibly slows down. It'll be interesting to see how long these refilled markers last.
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